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ey0017.11-10 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.10. The [beta]3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

BS Finlin , H Memetimin , B Zhu , AL Confides , HJ Vekaria , RH El Khouli , ZR Johnson , PM Westgate , J Chen , AJ Morris , PG Sullivan , EE Dupont-Versteegden , PA Kern

To read the full abstract: J Clin Invest. 2020;130(5):23192331.This clinical study assessed the effect of the β3-adrenergic agonist mirabegron on glucose homeostasis in obese individuals.Chronic activation of β3-receptors in mice leads to the appearance of brown-like (e.g. beige) adipocytes in white adipose tissue, a process referred to as ...

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ey0016.14-12 | (1) | ESPEYB16

14.12. Genome amplification and cellular senescence are hallmarks of human placenta development

P Velicky , G Meinhardt , K Plessl , S Vondra , T Weiss , P Haslinger , T Lendl , K Aumayr , M Mairhofer , X Zhu , B Schutz , RL Hannibal , R Lindau , B Weil , J Ernerudh , J Neesen , G Egger , M Mikula , C Rohrl , AE Urban , J Baker , M Knofler , J Pollheimer

To read the full abstract: PLoS Genet 2018;14:e1007698.These authors studied human placental and decidual tissues obtained from elective pregnancy terminations (612 weeks gestation). Placental extravillous trophoblasts (EVTs), the cells that rapidly invade the mothers endometrium, undergo an initial stage of genomewide amplification leadi...

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ESPE Yearbook of Paediatric Endocrinology

11.10. The [beta]3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

14.12. Genome amplification and cellular senescence are hallmarks of human placenta development

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